Reaction Details  Report a problem with these data
Target
Bromodomain testis-specific protein [22-138]
Ligand
BDBM543505
Substrate
n/a
Meas. Tech.
AlphaLisa Assay
IC50
406±n/a nM
Citation
 Upadhayaya, RS; Kethiri, R; Madan, S; Rajaiah, SK Fused pyrimidine compounds as BRD4 and JAK2 dual inhibitors and methods for use thereof US Patent  US11279703 Publication Date 3/22/2022
Target
Name:
Bromodomain testis-specific protein [22-138]
Synonyms:
BRDT | BRDT_HUMAN | Bromodomain testis-specific protein (BRDT)(BD1)
Type:
n/a
Mol. Mass.:
13948.58
Organism:
Homo sapiens (Human)
Description:
Q58F21[22-138]
Residue:
117
Sequence:
TKKNGRLTNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVKLQLPDYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQKLSQMPQEEQ
  
Inhibitor
Name:
BDBM543505
Synonyms:
US11279703, TABLE 5.3 | US11279703, TABLE 6.240 | US11279703, TABLE 6.291 | US11279703, TABLE 6.332
Type:
Small organic molecule
Emp. Form.:
C29H37N7O2S
Mol. Mass.:
547.715
SMILES:
CN(C)C1CCN(CC1)c1ccc(Nc2ncc3ccn(-c4cccc(NS(=O)(=O)C(C)(C)C)c4)c3n2)cc1
Structure:
Search PDB for entries with ligand similarity: