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Target
Cytochrome P450 26A1
Ligand
BDBM476238
Substrate
n/a
Meas. Tech.
Retinoid Activity Assays
IC50
1900±n/a nM
Citation
 Cameron, DA; Petkovich, M; Rantanen, TK; Snieckus, V; Board, J; Singh, S; Maheta, AJ Compounds and methods for inhibiting CPY26 enzymes US Patent  US11364220 Publication Date 6/21/2022
Target
Name:
Cytochrome P450 26A1
Synonyms:
CP26A_HUMAN | CYP26 | CYP26A1 | Cytochrome CYP26A1 | Cytochrome P450 26A1 | Cytochrome P450 retinoic acid-inactivating 1 | P450RAI1 | Retinoic acid 4-hydroxylase
Type:
Enzyme
Mol. Mass.:
56216.16
Organism:
Homo sapiens (Human)
Description:
O43174
Residue:
497
Sequence:
MGLPALLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPLPPGTMGFPFFGETLQMVLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTILGSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLLVYPEVKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKARNLIHARIEQNIRAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTVYPVDNLPARFTHFHGEI
  
Inhibitor
Name:
BDBM476238
Synonyms:
US10874634, Cmpd No. 21 | US11364220, Compound 21
Type:
Small organic molecule
Emp. Form.:
C21H27NO3S
Mol. Mass.:
373.509
SMILES:
Cc1ccc(NS(=O)(=O)c2cc(C)c3OC(C)(C)CC(C)(C)c3c2)cc1
Structure:
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