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Target
Arginase-1
Ligand
BDBM290426
Substrate
n/a
Meas. Tech.
Inhibition of Arginase
IC50
125±n/a nM
Citation
 Van Zandt, M; Jagdmann, GE Arginase inhibitors as therapeutics US Patent  US11389464 Publication Date 7/19/2022
Target
Name:
Arginase-1
Synonyms:
ARG1 | ARGI1_HUMAN | Liver-type arginase | Type I arginase
Type:
PROTEIN
Mol. Mass.:
34737.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_978893
Residue:
322
Sequence:
MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYLNPPK
  
Inhibitor
Name:
BDBM290426
Synonyms:
(1S,2S,4S)-1-amino-4-(benzylamino)-2-(3- boronopropyl)cyclopentanecarboxylic acid | US10098902, Example 62 | US10603330, Example 62 | US11389464, Example 62
Type:
Small organic molecule
Emp. Form.:
C16H25BN2O4
Mol. Mass.:
320.192
SMILES:
N[C@]1(C[C@H](C[C@@H]1CCCB(O)O)NCc1ccccc1)C(O)=O |r|
Structure:
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