Reaction Details  Report a problem with these data
Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM573684
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
EC50
5500±n/a nM
Citation
 Slassi, A; Araujo, J 3-pyrrolidine-indole derivatives as serotonergic psychedelic agents for the treatment of CNS disorders US Patent  US11453689 Publication Date 9/27/2022
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_HUMAN | HTR2 | HTR2A | Serotonin receptor 2A
Type:
undefined
Mol. Mass.:
52607.65
Organism:
Homo sapiens (Human)
Description:
P28223
Residue:
471
Sequence:
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
  
Inhibitor
Name:
BDBM573684
Synonyms:
3-(((R)-1- (methyl- d3)pyrrolidin-2- yl)methyl-d2)- 1H-indol-4-yl (9Z,12Z)- octadeca-9,12- dienoate | US11453689, Compound I-49
Type:
Small organic molecule
Emp. Form.:
C32H48N2O2
Mol. Mass.:
492.7357
SMILES:
CCCCC\C=C/C\C=C/CCCCCCCC(=O)Oc1cccc2[nH]cc(C[C@H]3CCCN3C)c12 |r|
Structure:
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