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Target
Retina-specific copper amine oxidase
Ligand
BDBM576489
Substrate
n/a
Meas. Tech.
SSAO Activity Assay
IC50
<20±n/a nM
Citation
 Ren, Z; Sun, X; Xu, Q SSAO inhibitors and use thereof US Patent  US11472769 Publication Date 10/18/2022
Target
Name:
Retina-specific copper amine oxidase
Synonyms:
AOC2 | AOC2_HUMAN | Retina-specific amine oxidase, copper containing
Type:
PROTEIN
Mol. Mass.:
83681.38
Organism:
Homo sapiens (Human)
Description:
ChEMBL_157252
Residue:
756
Sequence:
MHLKIVLAFLALSLITIFALAYVLLTSPGGSSQPPHCPSVSHRAQPWPHPGQSQLFADLSREELTAVMRFLTQRLGPGLVDAAQAQPSDNCIFSVELQLPPKAAALAHLDRGSPPPAREALAIVLFGGQPQPNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLRAEFTQMWRHLKEVELPKAPIFLSSTFNYNGSTLAAVHATPRGLRSGDRATWMALYHNISGVGLFLHPVGLELLLDHRALDPAHWTVQQVFYLGHYYADLGQLEREFKSGRLEVVRVPLPPPNGASSLRSRNSPGPLPPLQFSPQGSQYSVQGNLVVSSLWSFTFGHGVFSGLRIFDVRFQGERIAYEVSVQECVSIYGADSPKTMLTRYLDSSFGLGRNSRGLVRGVDCPYQATMVDIHILVGKGAVQLLPGAVCVFEEAQGLPLRRHHNYLQNHFYGGLASSALVVRSVSSVGNYDYIWDFVLYPNGALEGRVHATGYINTAFLKGGEEGLLFGNRVGERVLGTVHTHAFHFKLDLDVAGLKNWVVAEDVVFKPVAAPWNPEHWLQRPQLTRQVLGKEDLTAFSLGSPLPRYLYLASNQTNAWGHQRGYRIQIHSPLGIHIPLESDMERALSWGRYQLVVTQRKEEESQSSSIYHQNDIWTPTVTFADFINNETLLGEDLVAWVTASFLHIPHAEDIPNTVTLGNRVGFLLRPYNFFDEDPSIFSPGSVYFEKGQDAGLCSINPVACLPDLAACVPDLPPFSYHGF
  
Inhibitor
Name:
BDBM576489
Synonyms:
(E)-3-fluoro-2-((4-((((1s,4s)-4- methoxycyclohexyl)methyl)sulfonyl) phenoxy)methyl)prop-2-en-1-amine | US11472769, Compound 20
Type:
Small organic molecule
Emp. Form.:
C18H26FNO4S
Mol. Mass.:
371.467
SMILES:
CO[C@@H]1CC[C@H](CS(=O)(=O)c2ccc(OC\C(CN)=C\F)cc2)CC1 |r,wU:5.5,2.1,(-9.34,-3.08,;-8,-3.85,;-6.67,-3.08,;-5.33,-3.85,;-4,-3.08,;-4,-1.54,;-2.67,-.77,;-1.33,-1.54,;-2.1,-2.87,;-.56,-2.87,;,-.77,;1.33,-1.54,;2.67,-.77,;2.67,.77,;4,1.54,;5.33,.77,;6.67,1.54,;8,.77,;9.34,1.54,;6.67,3.08,;8,3.85,;1.33,1.54,;,.77,;-5.33,-.77,;-6.67,-1.54,)|
Structure:
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