Reaction Details  Report a problem with these data
Target
Histone acetyltransferase KAT7
Ligand
BDBM580679
Substrate
n/a
Meas. Tech.
Kat7 Assay
Ki
150±n/a nM
Citation
 Bozikis, YE; Camerino, MA; Kung, P; Stupple, PA; Sutton, SC Benzisoxazole sulfonamide derivatives US Patent  US11492346 Publication Date 11/8/2022
Target
Name:
Histone acetyltransferase KAT7
Synonyms:
2.3.1.48 | HBO1 | HBOa | Histone acetyltransferase KAT7 | Histone acetyltransferase binding to ORC1 | KAT7 | KAT7_HUMAN | Lysine acetyltransferase 7 | MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2 | MYST-2 | MYST2 | Synonyms=HBO1
Type:
PROTEIN
Mol. Mass.:
70665.79
Organism:
Homo sapiens
Description:
ChEMBL_116753
Residue:
611
Sequence:
MPRRKRNAGSSSDGTEDSDFSTDLEHTDSSESDGTSRRSARVTRSSARLSQSSQDSSPVRNLQSFGTEEPAYSTRRVTRSQQQPTPVTPKKYPLRQTRSSGSETEQVVDFSDRETKNTADHDESPPRTPTGNAPSSESDIDISSPNVSHDESIAKDMSLKDSGSDLSHRPKRRRFHESYNFNMKCPTPGCNSLGHLTGKHERHFSISGCPLYHNLSADECKVRAQSRDKQIEERMLSHRQDDNNRHATRHQAPTERQLRYKEKVAELRKKRNSGLSKEQKEKYMEHRQTYGNTREPLLENLTSEYDLDLFRRAQARASEDLEKLRLQGQITEGSNMIKTIAFGRYELDTWYHSPYPEEYARLGRLYMCEFCLKYMKSQTILRRHMAKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVMTEADNTGCHLIGYFSKEKNSFLNYNVSCILTMPQYMRQGYGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYLHNFQGKEISIKEISQETAVNPVDIVSTLQALQMLKYWKGKHLVLKRQDLIDEWIAKEAKRSNSNKTMDPSCLKWTPPKGT
  
Inhibitor
Name:
BDBM580679
Synonyms:
US11492346, Example 19
Type:
Small organic molecule
Emp. Form.:
C20H20N4O6S
Mol. Mass.:
444.461
SMILES:
COc1ccc(OC)c(c1)S(=O)(=O)Nc1noc2cc(Cn3cccn3)cc(OC)c12
Structure:
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