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Target
Mitogen-activated protein kinase kinase kinase kinase 1
Ligand
BDBM587483
Substrate
n/a
Meas. Tech.
MAP4K1 Biochemical Enzymatic Activity Assay
IC50
0.100±n/a nM
Citation
 Brubaker, JD; Miduturu, CV; Burke, MJ; Dineen, TA; Kim, JL; Close, JT; Perola, E MAP4K1 inhibitors US Patent  US11534441 Publication Date 12/27/2022
Target
Name:
Mitogen-activated protein kinase kinase kinase kinase 1
Synonyms:
HPK1 | M4K1_HUMAN | MAP4K1
Type:
PROTEIN
Mol. Mass.:
91316.07
Organism:
Homo sapiens (Human)
Description:
ChEMBL_586597
Residue:
833
Sequence:
MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSIGDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQPPRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQLSPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMKRKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVFALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDMVMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQLLQELRDPTLTFRLLGSPRLECSGTISPHCNLLLPGSSNSPASASRVAGITGL
  
Inhibitor
Name:
BDBM587483
Synonyms:
US11534441, Compound 193
Type:
Small organic molecule
Emp. Form.:
C27H31N5O4
Mol. Mass.:
489.5661
SMILES:
C[C@@H]1OC(=O)c2ccc(Nc3cc4c(cnc(O[C@H]5C[C@H](O)C5)c4cn3)[C@@](C)(N)C3CC3)nc2[C@H]1C |r,wU:26.29,18.17,34.40,wD:26.30,20.20,1.0,(8.16,8.71,;6.82,7.94,;6.82,6.4,;5.49,5.63,;5.49,4.09,;4.15,6.4,;2.82,5.63,;1.49,6.4,;1.49,7.94,;.15,8.71,;-1.18,7.94,;-2.51,8.71,;-3.85,7.94,;-5.18,8.71,;-6.51,7.94,;-6.51,6.4,;-5.18,5.63,;-5.18,4.09,;-3.85,3.32,;-2.36,3.72,;-1.96,2.23,;-.63,1.46,;-3.45,1.83,;-3.85,6.4,;-2.51,5.63,;-1.18,6.4,;-5.18,10.25,;-4.41,11.58,;-3.64,10.25,;-6.67,10.65,;-7.76,11.73,;-8.16,10.25,;2.82,8.71,;4.15,7.94,;5.49,8.71,;5.49,10.25,)|
Structure:
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