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Target
Kallikrein-6
Ligand
BDBM588054
Substrate
n/a
Meas. Tech.
Activities on KLK6 (MBP3)
IC50
7890±630 nM
Citation
 El Amri, C; Soualmia, F; Masurier, N; Aït Amiri, S; Nait Oumesmar, B; Deboux, C Compounds and compositions for the treatment of neurodegenerative and inflammatory diseases US Patent  US11541023 Publication Date 1/3/2023
Target
Name:
Kallikrein-6
Synonyms:
KLK6 | KLK6_HUMAN | Kallikrein 6 | PRSS18 | PRSS9
Type:
PROTEIN
Mol. Mass.:
26861.50
Organism:
Homo sapiens (Human)
Description:
ChEMBL_826901
Residue:
244
Sequence:
MKKLMVVLSLIAAAWAEEQNKLVHGGPCDKTSHPYQAALYTSGHLLCGGVLIHPLWVLTAAHCKKPNLQVFLGKHNLRQRESSQEQSSVVRAVIHPDYDAASHDQDIMLLRLARPAKLSELIQPLPLERDCSANTTSCHILGWGKTADGDFPDTIQCAYIHLVSREECEHAYPGQITQNMLCAGDEKYGKDSCQGDSGGPLVCGDHLRGLVSWGNIPCGSKEKPGVYTNVCRYTNWIQKTIQAK
  
Inhibitor
Name:
BDBM588054
Synonyms:
US11541023, Compound 2
Type:
Small organic molecule
Emp. Form.:
C18H16N2O2
Mol. Mass.:
292.3318
SMILES:
NCc1ccc(NC(=O)c2ccc3ccccc3c2O)cc1
Structure:
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