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Target
Kallikrein-1
Ligand
BDBM588058
Substrate
n/a
Meas. Tech.
Inhibitory Effect on the Enzymatic Activity of KLK
IC50
8440±280 nM
Citation
 El Amri, C; Soualmia, F; Masurier, N; Aït Amiri, S; Nait Oumesmar, B; Deboux, C Compounds and compositions for the treatment of neurodegenerative and inflammatory diseases US Patent  US11541023 Publication Date 1/3/2023
Target
Name:
Kallikrein-1
Synonyms:
KLK1 | KLK1_HUMAN | Kallikrein 1 | Kallikrein-1 | Kidney/pancreas/salivary gland kallikrein | Tissue kallikrein
Type:
Enzyme
Mol. Mass.:
28874.69
Organism:
Homo sapiens (Human)
Description:
P06870
Residue:
262
Sequence:
MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWVLTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHDLMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKILPNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNKPSVAVRVLSYVKWIEDTIAENS
  
Inhibitor
Name:
BDBM588058
Synonyms:
US11541023, Compound 6
Type:
Small organic molecule
Emp. Form.:
C17H20N2O2
Mol. Mass.:
284.3529
SMILES:
CC(C)c1ccc(C(=O)Nc2ccc(CN)cc2)c(O)c1
Structure:
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