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Target
Tyrosine-protein kinase BTK
Ligand
BDBM588161
Substrate
n/a
Meas. Tech.
BTK and EGFR in Vitro Assay
IC50
6.88±1.37 nM
Citation
 Henry, Jr., KJ; Khilevich, A; Kuklish, SL; Partridge, KM; Quimby, SJ BTK inhibitor compounds US Patent  US11542249 Publication Date 1/3/2023
Target
Name:
Tyrosine-protein kinase BTK
Synonyms:
AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK)
Type:
Enzyme
Mol. Mass.:
76289.95
Organism:
Homo sapiens (Human)
Description:
Q06187
Residue:
659
Sequence:
MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
  
Inhibitor
Name:
BDBM588161
Synonyms:
1-[(2S,3R)-3-[[6- [2-(3- chlorophenoxy) pyrimidin-5-yl]pyrazin- 2-yl]amino]-2- methyl-azetidin-1- yl]prop-2-en-1-one, Isomer 1 | US11542249, Example 32
Type:
Small organic molecule
Emp. Form.:
C21H19ClN6O2
Mol. Mass.:
422.868
SMILES:
C[C@H]1[C@@H](CN1C(=O)C=C)Nc1cncc(n1)-c1cnc(Oc2cccc(Cl)c2)nc1 |r|
Structure:
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