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Target
Protein SSX2/Protein SSXT
Ligand
BDBM590473
Substrate
n/a
Meas. Tech.
SYO1 BRD9 NanoLuc Degradation Assay
IC50
<10±n/a nM
Citation
 Ruppel, SK; Yang, Z; Lowe, JT; Voigt, JH; Netherton, M Compounds and uses thereof US Patent  US11560381 Publication Date 1/24/2023
Target
Name:
Protein SSX2/Protein SSXT
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Protein SSX2
Synonyms:
CT5.2 | Cancer/testis antigen 5.2 | SSX2 | SSX2A | SSX2_HUMAN | Synovial sarcoma, X breakpoint 2 | Tumor antigen HOM-MEL-40
Type:
Protein
Mol. Mass.:
21617.50
Organism:
Human
Description:
Q16385
Residue:
188
Sequence:
MNGDDAFARRPTVGAQIPEKIQKAFDDIAKYFSKEEWEKMKASEKIFYVYMKRKYEAMTKLGFKATLPPFMCNKRAEDFQGNDLDNDPNRGNQVERPQMTFGRLQGISPKIMPKKPAEEGNDSEEVPEASGPQNDGKELCPPGKPTTSEKIHERSGPKRGEHAWTHRLRERKQLVIYEEISDPEEDDE
  
Component 2
Name:
Protein SSXT
Synonyms:
Protein SYT | SS18 | SSXT | SSXT_HUMAN | SYT | Synovial sarcoma translocated to X chromosome protein
Type:
Protein
Mol. Mass.:
45928.28
Organism:
Human
Description:
Q15532
Residue:
418
Sequence:
MSVAFAAPRQRGKGEITPAAIQKMLDDNNHLIQCIMDSQNKGKTSECSQYQQMLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQLNMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPMGMMGQVNQGNHMMGQRQIPPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGHNDYGYQQPSYPEQGYDRPYEDSSQHYYEGGNSQYGQQQDAYQGPPPQQGYPPQQQQYPGQQGYPGQQQGYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQPPQQRPYGYDQGQYGNYQQ
  
Inhibitor
Name:
BDBM590473
Synonyms:
BDBM590479 | US11560381, Compound D282
Type:
Small organic molecule
Emp. Form.:
C38H39N8O8
Mol. Mass.:
735.7651
SMILES:
[H].[#6]-[#8]-c1cc(cc(-[#8]-[#6])c1-[#6]-[#7](-[#6])-[#6]-[#6]-[#6]-n1cc(-[#6]-[#8]-c2ccc3-[#6](=O)-[#7](-[#6]-4-[#6]-[#6]-[#6](=O)-[#7]-[#6]-4=O)-[#6](=O)-c3c2)nn1)-c1cn(-[#6])c(=O)c2cnccc12
Structure:
Search PDB for entries with ligand similarity: