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Target
Protein SSX2/Protein SSXT
Ligand
BDBM590516
Substrate
n/a
Meas. Tech.
SYO1 BRD9 NanoLuc Degradation Assay
IC50
<10±n/a nM
Citation
 Ruppel, SK; Yang, Z; Lowe, JT; Voigt, JH; Netherton, M Compounds and uses thereof US Patent  US11560381 Publication Date 1/24/2023
Target
Name:
Protein SSX2/Protein SSXT
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Protein SSX2
Synonyms:
CT5.2 | Cancer/testis antigen 5.2 | SSX2 | SSX2A | SSX2_HUMAN | Synovial sarcoma, X breakpoint 2 | Tumor antigen HOM-MEL-40
Type:
Protein
Mol. Mass.:
21617.50
Organism:
Human
Description:
Q16385
Residue:
188
Sequence:
MNGDDAFARRPTVGAQIPEKIQKAFDDIAKYFSKEEWEKMKASEKIFYVYMKRKYEAMTKLGFKATLPPFMCNKRAEDFQGNDLDNDPNRGNQVERPQMTFGRLQGISPKIMPKKPAEEGNDSEEVPEASGPQNDGKELCPPGKPTTSEKIHERSGPKRGEHAWTHRLRERKQLVIYEEISDPEEDDE
  
Component 2
Name:
Protein SSXT
Synonyms:
Protein SYT | SS18 | SSXT | SSXT_HUMAN | SYT | Synovial sarcoma translocated to X chromosome protein
Type:
Protein
Mol. Mass.:
45928.28
Organism:
Human
Description:
Q15532
Residue:
418
Sequence:
MSVAFAAPRQRGKGEITPAAIQKMLDDNNHLIQCIMDSQNKGKTSECSQYQQMLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQLNMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPMGMMGQVNQGNHMMGQRQIPPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGHNDYGYQQPSYPEQGYDRPYEDSSQHYYEGGNSQYGQQQDAYQGPPPQQGYPPQQQQYPGQQGYPGQQQGYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQPPQQRPYGYDQGQYGNYQQ
  
Inhibitor
Name:
BDBM590516
Synonyms:
US11560381, Compound D325
Type:
Small organic molecule
Emp. Form.:
C40H38N6O9
Mol. Mass.:
746.7645
SMILES:
COc1cc(cc(OC)c1CN1CCC(CC1)c1nc(COc2ccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c3c2)co1)-c1cn(C)c(=O)c2cnccc12
Structure:
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