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Target
Vasopressin V1a receptor
Ligand
BDBM593649
Substrate
n/a
Meas. Tech.
Pharmacological Assay
Ki
2.00±n/a nM
Citation
 Runtz-Schmitt, V; Schnider, P; Dolente, C; Fasching, B Spiro-oxazolones US Patent  US11578077 Publication Date 2/14/2023
Target
Name:
Vasopressin V1a receptor
Synonyms:
AVPR V1a | AVPR1 | AVPR1A | Antidiuretic hormone receptor 1a | V1AR_HUMAN | V1aR | VASOPRESSIN V1A | Vascular/hepatic-type arginine vasopressin receptor | Vasopressin V1 receptor | Vasopressin V1a receptor | Vasopressin receptor
Type:
Receptor
Mol. Mass.:
46820.18
Organism:
Homo sapiens (Human)
Description:
P37288
Residue:
418
Sequence:
MRLSAGPDAGPSGNSSPWWPLATGAGNTSREAEALGEGNGPPRDVRNEELAKLEIAVLAVTFAVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQMCWDITYRFRGPDWLCRVVKHLQVFGMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIAAAWVLSFVLSTPQYFVFSMIEVNNVTKARDCWATFIQPWGSRAYVTWMTGGIFVAPVVILGTCYGFICYNIWCNVRGKTASRQSKGAEQAGVAFQKGFLLAPCVSSVKSISRAKIRTVKMTFVIVTAYIVCWAPFFIIQMWSVWDPMSVWTESENPTITITALLGSLNSCCNPWIYMFFSGHLLQDCVQSFPCCQNMKEKFNKEDTDSMSRRQTFYSNNRSPTNSTGMWKDSPKSSKSIKFIPVST
  
Inhibitor
Name:
BDBM593649
Synonyms:
2'-(3-methyl-1'H,5H-spiro[furo[3,4- b]pyridine-7,4'-piperidin]-1'-yl)-1,3- dihydro-4'H-spiro[indene-2,5'- [1,3]oxazol]-4'-one | US11578077, Example 44
Type:
Small organic molecule
Emp. Form.:
C23H23N3O3
Mol. Mass.:
389.447
SMILES:
Cc1cnc2c(COC22CCN(CC2)C2=NC(=O)C3(Cc4ccccc4C3)O2)c1 |t:16|
Structure:
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