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Target
cAMP-specific 3',5'-cyclic phosphodiesterase 7B
Ligand
BDBM607204
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
55.0±n/a nM
Citation
 Santora, VJ; Chen, M; Chung, D Substituted benzoxazole and benzofuran compounds as PDE7 inhibitors US Patent  US11685745 Publication Date 6/27/2023
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 7B
Synonyms:
3',5'-cyclic phosphodiesterase | PDE7B | PDE7B_HUMAN | Phosphodiesterase 7B | Phosphodiesterase 7B (PDE7B) | cAMP-specific 3',5'-cyclic phosphodiesterase 7B
Type:
Enzyme
Mol. Mass.:
51842.76
Organism:
Homo sapiens (Human)
Description:
Q9NP56
Residue:
450
Sequence:
MSCLMVERCGEILFENPDQNAKCVCMLGDIRLRGQTGVRAERRGSYPFIDFRLLNSTTYSGEIGTKKKVKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSVLENHHWRSTIGMLRESRLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHNKDLRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEISPLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQWKSLLPRQHRSRGSSGSGPDHDHAGQGTESEEQEGDSP
  
Inhibitor
Name:
BDBM607204
Synonyms:
US11685745, Example 128
Type:
Small organic molecule
Emp. Form.:
C22H28ClN5O2
Mol. Mass.:
429.943
SMILES:
Clc1cc2nc(CN3CCN4CCC[C@@H]4C3)oc2c2c1NC(=O)NC21CCCCC1 |r|
Structure:
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