Target
Dipeptidyl peptidase 1
Ligand
BDBM385044
Substrate
n/a
Meas. Tech.
Fluorescence Assay for Recombinant Human (RH) DPP1
IC50
79.4±n/a nM
Citation
 LÖNN, HRCONNOLLY, SSWALLOW, SKARLSSON, SPAURELL, CPONTÉN, JFDOYLE, KJVAN DE POËL, AJJONES, GPWATSON, DWMACRITCHIE, JAPALMER, NJ CERTAIN (2S)-N-[(1S)-1-CYANO-2-PHENYLETHYL]-1,4-OXAZEPANE-2-CARBOXAMIDES AS DIPEPTIDYL PEPTIDASE 1 INHIBITORS US Patent  US20230278969 Publication Date 9/7/2023
Target
Name:
Dipeptidyl peptidase 1
Synonyms:
CATC_HUMAN | CPPI | CTSC | Cathepsin C | Cathepsin J | Dipeptidyl peptidase 1 (DDPI) | Dipeptidyl peptidase 1 (DPPI) | Dipeptidyl peptidase I | Dipeptidyl peptidase I (DPPI)
Type:
Enzyme
Mol. Mass.:
51857.28
Organism:
Homo sapiens (Human)
Description:
P53634
Residue:
463
Sequence:
MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL
  
Inhibitor
Name:
BDBM385044
Synonyms:
4′-[(2S)-2-Cyano-2-{[(2S)-1,4-oxazepan-2-ylcarbonyl]amino}ethyl]biphenyl-3-yl methanesulfonate | US10287258, Example 4 | US10669245, Example 4 | US11117874, Example 4 | US11667615, Example 4 | US11680049, Example 4 | US20230278969, Example 4
Type:
Small organic molecule
Emp. Form.:
C22H25N3O5S
Mol. Mass.:
443.516
SMILES:
CS(=O)(=O)Oc1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1
Structure:
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