Reaction Details  Report a problem with these data
Target
Dipeptidyl peptidase 1
Ligand
BDBM385071
Substrate
n/a
Meas. Tech.
Fluorescence Assay for Recombinant Human (RH) DPP1
IC50
21.4±n/a nM
Citation
 LÖNN, HR; CONNOLLY, S; SWALLOW, S; KARLSSON, SP; AURELL, C; PONTÉN, JF; DOYLE, KJ; VAN DE POËL, AJ; JONES, GP; WATSON, DW; MACRITCHIE, JA; PALMER, NJ CERTAIN (2S)-N-[(1S)-1-CYANO-2-PHENYLETHYL]-1,4-OXAZEPANE-2-CARBOXAMIDES AS DIPEPTIDYL PEPTIDASE 1 INHIBITORS US Patent  US20230278969 Publication Date 9/7/2023
Target
Name:
Dipeptidyl peptidase 1
Synonyms:
CATC_HUMAN | CPPI | CTSC | Cathepsin C | Cathepsin J | Dipeptidyl peptidase 1 (DDPI) | Dipeptidyl peptidase 1 (DPPI) | Dipeptidyl peptidase I | Dipeptidyl peptidase I (DPPI)
Type:
Enzyme
Mol. Mass.:
51857.28
Organism:
Homo sapiens (Human)
Description:
P53634
Residue:
463
Sequence:
MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL
  
Inhibitor
Name:
BDBM385071
Synonyms:
(2S)-N-{(1S)-2-[4'-(Azetidin-1-ylsulfonyl)biphenyl-4-yl]-1-cyanoethyl}-1,4-oxazepane- 2-carboxamide | US10287258, Example 31 | US10669245, Example 31 | US11117874, Example 31 | US11655221, Example 31 | US11667615, Example 31 | US11680049, Example 31 | US20230278969, Example 31
Type:
Small organic molecule
Emp. Form.:
C24H28N4O4S
Mol. Mass.:
468.569
SMILES:
O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N1CCC1)C#N)[C@@H]1CNCCCO1
Structure:
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