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Target
L-lactate dehydrogenase B chain
Ligand
BDBM488247
Substrate
n/a
Meas. Tech.
Inhibition of LDHB Activity
IC50
<100±n/a nM
Citation
 Hall, M; Urban, DJ; Knight, J; Holmes, R; Wood, KD; Waterson, A; Darley-Usmar, VM; Neckers, LM Treating primary or idiopathic hyperoxaluria with small molecule inhibitors of lactate dehydrogenase US Patent  US11752138 Publication Date 9/12/2023
Target
Name:
L-lactate dehydrogenase B chain
Synonyms:
L-lactate dehydrogenase B | L-lactate dehydrogenase B chain | LDH heart subunit | LDH-B | LDH-H | LDHB | LDHB_HUMAN | Lactate dehydrogenase B (LDHB) | Renal carcinoma antigen NY-REN-46
Type:
Oxidoreductase; homotetramer
Mol. Mass.:
36635.55
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
334
Sequence:
MATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMACAISILGKSLADELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIVKYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVESAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYGIENEVFLSLPCILNARGLTSVINQKLKDDEVAQLKKSADTLWDIQKDLKDL
  
Inhibitor
Name:
BDBM488247
Synonyms:
2-(5-(cyclopropylmethyl)- 3-(4-fluoro-3-(2- oxopyrrolidin-1-yl) phenyl)-4-(3-fluoro-4- sulfamoylbenzyl)-1H- pyrazol-1-yl)thiazole-4- carboxylic acid | US10954228, Compound 202 | US11752138, Compound 202
Type:
Small organic molecule
Emp. Form.:
C28H25F2N5O5S2
Mol. Mass.:
613.655
SMILES:
NS(=O)(=O)c1ccc(Cc2c(CC3CC3)n(nc2-c2ccc(F)c(c2)N2CCCC2=O)-c2nc(cs2)C(O)=O)cc1F
Structure:
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