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Target
Interleukin-17F
Ligand
BDBM617534
Substrate
n/a
Meas. Tech.
AlphaLISA Assay
IC50
63.1±n/a nM
Citation
 MARTIN, BP; WESTERMANN, J; KERN, OT; HOLMES, AJ; MORRISON, A; KICZUN, M; AL MASRI, M; SMITH, A; HUXLEY, A IL-17A MODULATORS US Patent  US20230286943 Publication Date 9/14/2023
Target
Name:
Interleukin-17F
Synonyms:
Cytokine ML-1 | IL17F | IL17F_HUMAN | il-17f
Type:
Enzyme Catalytic Domain
Mol. Mass.:
18053.35
Organism:
Homo sapiens (Human)
Description:
Q96PD4
Residue:
163
Sequence:
MTVKTLHGPAMVKYLLLSILGLAFLSEAAARKIPKVGHTFFQKPESCPPVPGGSMKLDIGIINENQRVSMSRNIESRSTSPWNYTVTWDPNRYPSEVVQAQCRNLGCINAQGKEDISMNSVPIQQETLVVRRKHQGCSVSFQLEKVLVTVGCTCVTPVIHHVQ
  
Inhibitor
Name:
BDBM617534
Synonyms:
US20230286943, Example 2
Type:
Small organic molecule
Emp. Form.:
C27H32FN5O3
Mol. Mass.:
493.5731
SMILES:
C[C@H]1CC[C@@H](CC1)[C@H](NC(=O)c1ccnn1C)C(=O)Nc1ccc(c(F)c1)-c1ccc(=O)n(C)c1C |r,wU:1.0,wD:4.7,7.8,(2.74,5.84,;2.74,4.3,;4.08,3.53,;4.08,1.99,;2.74,1.22,;1.41,1.99,;1.41,3.53,;2.78,-.31,;4.11,-1.08,;5.45,-.31,;5.45,1.23,;6.78,-1.08,;6.94,-2.62,;8.45,-2.94,;9.22,-1.6,;8.19,-.46,;8.48,1.05,;1.44,-1.08,;1.44,-2.62,;.11,-.31,;-1.22,-1.08,;-1.22,-2.62,;-2.56,-3.39,;-3.89,-2.62,;-3.89,-1.08,;-5.22,-.31,;-2.56,-.31,;-5.2,-3.44,;-5.2,-4.98,;-6.53,-5.75,;-7.87,-4.98,;-9.14,-5.84,;-7.87,-3.44,;-9.22,-2.69,;-6.53,-2.67,;-6.53,-1.13,)|
Structure:
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