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Target
GTPase KRas [G12C,C51S,C80L,C118S]
Ligand
BDBM625380
Substrate
n/a
Meas. Tech.
Biochemical Functional Assay
IC50
47.8±n/a nM
Citation
 ZHANG, G; MIAO, J; WANG, C IMIDAZOTRIAZINE AND PYRROLOPYRIMIDINE DERIVATIVES AS KRAS G12C INHIBITORS US Patent  US20230322788 Publication Date 10/12/2023
Target
Name:
GTPase KRas [G12C,C51S,C80L,C118S]
Synonyms:
GTPase KRas (1-169)(G12C)(C51S)(C80L)(C118S)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
19417.19
Organism:
Homo sapiens (Human)
Description:
P01116[G12C,C51S,C80L,C118S]
Residue:
169
Sequence:
MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETSLLDILDTAGQEEYSAMRDQYMRTGEGFLLVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKSDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK
  
Inhibitor
Name:
BDBM625380
Synonyms:
US20230322788, Compound A7
Type:
Small organic molecule
Emp. Form.:
C32H36N8O2
Mol. Mass.:
564.6806
SMILES:
CN1CCC[C@H]1COc1nc(N2CCN([C@@H](CC#N)C2)C(=O)C=C)c2ncc(Cc3cccc4cccc(C)c34)n2n1 |r|
Structure:
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