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Target
GTPase KRas [G12C,C51S,C80L,C118S]
Ligand
BDBM625398
Substrate
n/a
Meas. Tech.
Biochemical Functional Assay
IC50
13.0±n/a nM
Citation
 ZHANG, G; MIAO, J; WANG, C IMIDAZOTRIAZINE AND PYRROLOPYRIMIDINE DERIVATIVES AS KRAS G12C INHIBITORS US Patent  US20230322788 Publication Date 10/12/2023
Target
Name:
GTPase KRas [G12C,C51S,C80L,C118S]
Synonyms:
GTPase KRas (1-169)(G12C)(C51S)(C80L)(C118S)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
19417.19
Organism:
Homo sapiens (Human)
Description:
P01116[G12C,C51S,C80L,C118S]
Residue:
169
Sequence:
MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETSLLDILDTAGQEEYSAMRDQYMRTGEGFLLVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKSDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK
  
Inhibitor
Name:
BDBM625398
Synonyms:
US20230322788, Compound B2
Type:
Small organic molecule
Emp. Form.:
C34H39N7O3
Mol. Mass.:
593.7186
SMILES:
CCn1cc(Cc2cc(O)cc3ccccc23)c2nc(OC[C@@H]3CCCN3C)nc(N3CCN([C@@H](CC#N)C3)C(=O)C=C)c12 |r|
Structure:
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