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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM634505
Substrate
n/a
Meas. Tech.
Measurement of Human IRAK-4 Inhibitory Activity
IC50
0.790±n/a nM
Citation
 ITO, T; TAKASHIMA, M; ATOBE, M; ARAI, K; TOYAMA, T; YOSHII, Y; POTTER, AJ; MADDOX, DP; RAY, S; FOLOPPE, N MACROCYCLIC COMPOUND US Patent  US20230357271 Publication Date 11/9/2023
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM634505
Synonyms:
US20230357271, Example a-01-11
Type:
Small organic molecule
Emp. Form.:
C22H26N6O3S
Mol. Mass.:
454.545
SMILES:
CN1CC[C@H]2C[C@H]1C(=O)NCCCOc1c(ccc3ncc(N2)nc13)-c1cnc(CO)s1
Structure:
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