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Target
5-hydroxytryptamine receptor 7
Ligand
BDBM638775
Substrate
n/a
Meas. Tech.
hPGDH Inhibitor Screening Biochemical Assay
IC50
<100±n/a nM
Citation
 RAI, R; BOOTH, R INHALED FORMULATIONS OF PGDH INHIBITORS AND METHODS OF USE THEREOF US Patent  US20230390274 Publication Date 12/7/2023
Target
Name:
5-hydroxytryptamine receptor 7
Synonyms:
5-HT-7 | 5-HT-X | 5-HT7 | 5-HT7L | 5-HT7S | 5-HT7b | 5HT7 | 5HT7R_HUMAN | HTR7 | Serotonin receptor 7
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
53573.08
Organism:
Homo sapiens (Human)
Description:
P34969
Residue:
479
Sequence:
MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
  
Inhibitor
Name:
BDBM638775
Synonyms:
US20230390274, Compound A-57
Type:
Small organic molecule
Emp. Form.:
C18H16ClFN4O
Mol. Mass.:
358.797
SMILES:
FC1CCN(CC1)C(=O)c1cnc2n(cc(Cl)c2c1)-c1cccnc1
Structure:
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