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Target
Diacylglycerol kinase alpha
Ligand
BDBM640990
Substrate
n/a
Meas. Tech.
In vitro DGK alpha and DGK delta Inhibition Assays
IC50
<20±n/a nM
Citation
 Hummel, J; Hie, L; Lacharity, JJ; Li, X; Manns, S; Qian, D; Wang, X; Wei, B; Xu, M TRICYCLIC TRIAZOLO COMPOUNDS AS DGK INHIBITORS US Patent  US20230399342 Publication Date 12/14/2023
Target
Name:
Diacylglycerol kinase alpha
Synonyms:
2.7.1.107 | 80 kDa diacylglycerol kinase | DAG kinase alpha | DAGK | DAGK1 | DGK-alpha | DGKA | DGKA_HUMAN | Diacylglycerol kinase alpha | Diglyceride kinase alpha
Type:
PROTEIN
Mol. Mass.:
82631.86
Organism:
Homo sapiens
Description:
ChEMBL_117392
Residue:
735
Sequence:
MAKERGLISPSDFAQLQKYMEYSTKKVSDVLKLFEDGEMAKYVQGDAIGYEGFQQFLKIYLEVDNVPRHLSLALFQSFETGHCLNETNVTKDVVCLNDVSCYFSLLEGGRPEDKLEFTFKLYDTDRNGILDSSEVDKIILQMMRVAEYLDWDVSELRPILQEMMKEIDYDGSGSVSQAEWVRAGATTVPLLVLLGLEMTLKDDGQHMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKYTVHDQCAMKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQAVGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNLSTSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQNLAKILKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLEGAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPMLMGPPPRSTNFFGFLS
  
Inhibitor
Name:
BDBM640990
Synonyms:
US20230399342, Example 65
Type:
Small organic molecule
Emp. Form.:
C27H34BrF2N9
Mol. Mass.:
602.52
SMILES:
C[C@@H]1CN([C@@H](C)CN1C(C1CC(F)(F)C1)c1ccc(Br)cc1)c1nc2nncn2c2n(CCN(C)C)cnc12 |r|
Structure:
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