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Target
Lysine-specific histone demethylase 1A
Ligand
BDBM645362
Substrate
n/a
Meas. Tech.
LSD1 in vitro activity assay
IC50
68.2±0.37 nM
Citation
 Liu, H; Li, J; Zhu, W; Zhou, Y; Wang, J; Su, M; Wang, S; Xu, W; Li, C; Kan, W; Jiang, H; Chen, K Trans-indoline cyclopropylamine chemical compound, and method for preparation, pharmaceutical composition, and use thereof US Patent  US11873292 Publication Date 1/16/2024
Target
Name:
Lysine-specific histone demethylase 1A
Synonyms:
AOF2 | BRAF35-HDAC complex protein BHC110 | Flavin-containing amine oxidase domain-containing protein 2 | KDM1 | KDM1A | KDM1A_HUMAN | KIAA0601 | LSD1 | Lysine-specific demethylase 1 (LSD1) | Lysine-specific histone demethylase 1 | Lysine-specific histone demethylase 1 (LSD1)
Type:
Enzyme
Mol. Mass.:
92901.01
Organism:
Homo sapiens (Human)
Description:
O60341
Residue:
852
Sequence:
MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTVVPGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSGVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQATPGVPAQQSPSM
  
Inhibitor
Name:
BDBM645362
Synonyms:
US11873292, Compound A18 | trans-4-((2-(1-(phenylsulfonyl) indolin-5-yl)cyclopropylamino)methyl) cyclohexylamine
Type:
Small organic molecule
Emp. Form.:
C24H31N3O2S
Mol. Mass.:
425.587
SMILES:
NC1CCC(CNC2CC2c2ccc3N(CCc3c2)S(=O)(=O)c2ccccc2)CC1 |(9.62,5.36,;8.29,4.59,;8.29,3.05,;6.95,2.28,;5.62,3.05,;4.29,2.28,;2.95,3.05,;1.86,1.97,;1.09,3.3,;.32,1.97,;-1.01,1.2,;-1.01,-.34,;-2.34,-1.11,;-3.68,-.34,;-5.14,-.82,;-6.05,.43,;-5.14,1.67,;-3.68,1.2,;-2.34,1.97,;-5.62,-2.28,;-4.08,-2.28,;-4.85,-3.62,;-6.95,-3.05,;-8.29,-2.28,;-9.62,-3.05,;-9.62,-4.59,;-8.29,-5.36,;-6.95,-4.59,;5.62,4.59,;6.95,5.36,)|
Structure:
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