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Target
Dihydroorotate dehydrogenase (quinone), mitochondrial
Ligand
BDBM50591156
Substrate
n/a
Meas. Tech.
hDHODH inhibition assay
IC50
18.0±4 nM
Citation
 Boschi, D; Giorgis, M; Lolli, ML; Martinelli, G; Saglio, G PYRAZOLO DERIVATIVES AS HUMAN DIHYDROOROTATE DEHYDROGENASE (HDHODH) INHIBITORS FOR USE AS ANTIVIRALS US Patent  US20240034730 Publication Date 2/1/2024
Target
Name:
Dihydroorotate dehydrogenase (quinone), mitochondrial
Synonyms:
DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN
Type:
Enzyme
Mol. Mass.:
42881.33
Organism:
Homo sapiens (Human)
Description:
Q02127
Residue:
395
Sequence:
MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
  
Inhibitor
Name:
BDBM50591156
Synonyms:
CHEMBL5196292 | US20240034730, Compound 37
Type:
Small organic molecule
Emp. Form.:
C25H22F3N3O3
Mol. Mass.:
469.4557
SMILES:
CC(C)c1cc(Oc2ccc(cc2)C(F)(F)F)c(C)cc1NC(=O)c1c(O)nn2ccccc12
Structure:
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