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Target
Diacylglycerol kinase delta
Ligand
BDBM649820
Substrate
n/a
Meas. Tech.
Evaluation of DGKdelta Inhibitory Effect
IC50
0.420±n/a nM
Citation
 Watanabe, H; Kamikubo, T; Kamikawa, A; Washio, T; Seki, Y; Okuyama, K; Ikeda, O; Tomiyama, H; Iwai, Y; Nakamura, A; Miyasaka, K HETEROARYL CARBOXAMIDE COMPOUND US Patent  US20240043403 Publication Date 2/8/2024
Target
Name:
Diacylglycerol kinase delta
Synonyms:
130 kDa diacylglycerol kinase | DAG kinase delta | DGK-delta | Diglyceride kinase delta
Type:
Protein
Mol. Mass.:
134541.20
Organism:
Human
Description:
Q16760
Residue:
1214
Sequence:
MAAAAGAPPPGPPQPPPPPPPEESSDSEPEAEPGSPQKLIRKVSTSGQIRQKTIIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKSIIFDEVDLTDASVAESSTKNVNNSFTVITPCRKLILCADNRKEMEDWIAALKTVQNREHFEPTQYSMDHFSGMHNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKESLLTKCPLGLCKVSVIPPTALNSIDSDGFWKASCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLNLHKQCQLGVLPLGTGNDLARVLGWGSACDDDTQLPQILEKLERASTKMLDRWSVMAYEAKLPRQASSSTVTEDFSEDSEVQQILFYEDSVAAHLSKILTSDQHSVVISSAKVLCETVKDFVARVGKAYEKTTESSEESEVMAKKCSVLKEKLDSLLKTLDDESQASSSLPNPPPTIAEEAEDGDGSGSICGSTGDRLVASACPARPQIFRPREQLMLRANSLKKAIRQIIEHTEKAVDEQNAQTQEQEGFVLGLSESEEKMDHRVCPPLSHSESFGVPKGRSQRKVSKSPCEKLISKGSLSLGSSASLPPQPGSRDGLPALNTKILYPNVRAGMSGSLPGGSVISRLLINADPFNSEPETLEYYTEKCVMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVLLECDGRPIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAVFGSMQMAVSRVIRLQHHRIAQCRTVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNRAQTLTRDRAFESTLKSWEDKQKCELPRPPSCSLHPEMLSEEEATQMDQFGQAAGVLIHSIREIAQSHRDMEQELAHAVNASSKSMDRVYGKPRTTEGLNCSFVLEMVNNFRALRSETELLLSGKMALQLDPPQKEQLGSALAEMDRQLRRLADTPWLCQSAEPGDEESVMLDLAKRSRSGKFRLVTKFKKEKNNKNKEAHSSLGAPVHLWGTEEVAAWLEHLSLCEYKDIFTRHDIRGSELLHLERRDLKDLGVTKVGHMKRILCGIKELSRSAPAVEA
  
Inhibitor
Name:
BDBM649820
Synonyms:
US20240043403, Example 57
Type:
Small organic molecule
Emp. Form.:
C26H25Cl2N7O3
Mol. Mass.:
554.428
SMILES:
CN1CCN(C[C@@H]1CN)c1c(NC(=O)c2coc(n2)-c2ccnnc2)ccc(Oc2ccccc2Cl)c1Cl |r|
Structure:
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