Reaction Details  Report a problem with these data
Target
High affinity immunoglobulin epsilon receptor subunit alpha [Y156A]
Ligand
BDBM659587
Substrate
n/a
Meas. Tech.
Fluorescence Resonance Energy Transfer (FRET) Assay.
IC50
75.0±n/a nM
Citation
 NORMAN, TJ; ZHU, Z; SUGANTHAN, S; RAMPALAKO, K; MADDEN, J; HEER, JP; FRANKLIN, RJ; CONNELLY, RL; DEMAUDE, T; HASLETT, GW; LALLEMAND, B; MONCK, NJ; ROWLEY, JH; TRANI, G DIHYDRO-CYCLOPENTA-ISOQUINOLINE SULFONAMIDES DERIVATIVES US Patent  US20240092773 Publication Date 3/21/2024
Target
Name:
High affinity immunoglobulin epsilon receptor subunit alpha [Y156A]
Synonyms:
High affinity immunoglobulin epsilon receptor subunit alpha [Y131A]
Type:
PROTEIN
Mol. Mass.:
29503.90
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
257
Sequence:
MAPAMESPTLLCVALLFFAPDGVLAVPQKPKVSLNPPWNRIFKGENVTLTCNGNNFFEVSSTKWFHNGSLSEETNSSLNIVNAKFEDSGEYKCQHQQVNESEPVYLEVFSDWLLLQASAEVVMEGQPLFLRCHGWRNWDVYKVIYYKDGEALKYWAENHNISITNATVEDSGTYYCTGKVWQLDYESEPLNITVIKAPREKYWLQFFIPLLVVILFAVDTGLFISTQQQVTFLLKIKRTRKGFRLLNPHPKPNPKNN
  
Inhibitor
Name:
BDBM659587
Synonyms:
3-cyclopropyl-N-(2- fluoro-2- methylpropyl)-9- (pyrimidin-5- ylamino)-8,9- dihydro-7H- cyclopenta[h] isoquinoline- 5-sulfonamide | US20240092773, Example 28
Type:
Small organic molecule
Emp. Form.:
C23H26FN5O2S
Mol. Mass.:
455.548
SMILES:
CC(C)(F)CNS(=O)(=O)c1cc2CCC(Nc3cncnc3)c2c2cnc(cc12)C1CC1
Structure:
Search PDB for entries with ligand similarity: