Reaction Details  Report a problem with these data
Target
High affinity immunoglobulin epsilon receptor subunit alpha [Y156A]
Ligand
BDBM659591
Substrate
n/a
Meas. Tech.
Fluorescence Resonance Energy Transfer (FRET) Assay.
IC50
75.0±n/a nM
Citation
 NORMAN, TJ; ZHU, Z; SUGANTHAN, S; RAMPALAKO, K; MADDEN, J; HEER, JP; FRANKLIN, RJ; CONNELLY, RL; DEMAUDE, T; HASLETT, GW; LALLEMAND, B; MONCK, NJ; ROWLEY, JH; TRANI, G DIHYDRO-CYCLOPENTA-ISOQUINOLINE SULFONAMIDES DERIVATIVES US Patent  US20240092773 Publication Date 3/21/2024
Target
Name:
High affinity immunoglobulin epsilon receptor subunit alpha [Y156A]
Synonyms:
High affinity immunoglobulin epsilon receptor subunit alpha [Y131A]
Type:
PROTEIN
Mol. Mass.:
29503.90
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
257
Sequence:
MAPAMESPTLLCVALLFFAPDGVLAVPQKPKVSLNPPWNRIFKGENVTLTCNGNNFFEVSSTKWFHNGSLSEETNSSLNIVNAKFEDSGEYKCQHQQVNESEPVYLEVFSDWLLLQASAEVVMEGQPLFLRCHGWRNWDVYKVIYYKDGEALKYWAENHNISITNATVEDSGTYYCTGKVWQLDYESEPLNITVIKAPREKYWLQFFIPLLVVILFAVDTGLFISTQQQVTFLLKIKRTRKGFRLLNPHPKPNPKNN
  
Inhibitor
Name:
BDBM659591
Synonyms:
US20240092773, Example 86
Type:
Small organic molecule
Emp. Form.:
C26H31FN8O2S
Mol. Mass.:
538.64
SMILES:
Cc1cc(Nc2nncn2[C@H]2CCc3c2cc(c2cc(ncc32)C2CC2)S(=O)(=O)NCC(C)(C)F)n(C)n1 |r|
Structure:
Search PDB for entries with ligand similarity: