Reaction Details  Report a problem with these data
Target
Sepiapterin reductase
Ligand
BDBM659937
Substrate
n/a
Meas. Tech.
Measurement of Human SPR Inhibitory Activity Assay
IC50
0.650±n/a nM
Citation
 KAMAURA, M; INABA, Y; SHINTANI, Y; KUWANO, Y; NAKAO, M; NAGAI, H; KUROSE, N; TAKAYA, K; NAKAJIMA, M CONDENSED HETEROCYCLIC COMPOUND US Patent  US20240092784 Publication Date 3/21/2024
Target
Name:
Sepiapterin reductase
Synonyms:
SPR | SPRE_HUMAN | Sepiapterin reductase (SPR)
Type:
Enzyme
Mol. Mass.:
28050.66
Organism:
Homo sapiens (Human)
Description:
P35270
Residue:
261
Sequence:
MEGGLGRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSGLRVVRVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQVNNYWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDMLFQVLALEEPNVRVLNYAPGPLDTDMQQLARETSVDPDMRKGLQELKAKGKLVDCKVSAQKLLSLLEKDEFKSGAHVDFYDK
  
Inhibitor
Name:
BDBM659937
Synonyms:
3-((E)-3-((1S,4S)-2-Oxa-5-azabicyclo[2.2.1]heptan-5-yl)-3-oxoprop-1-en-1-yl N-cyclopropyl-7-hydroxy-4-((1-methylcyclopropyl)methyl)-5-oxo-4,5-dihydropyrazolo[1,5-a]pyrimidine-6-carboxamide | US20240092784, Example 374
Type:
Small organic molecule
Emp. Form.:
C23H27N5O5
Mol. Mass.:
453.491
SMILES:
CC1(Cn2c3c(\C=C\C(=O)N4C[C@H]5C[C@@H]4CO5)cnn3c(O)c(C(=O)NC3CC3)c2=O)CC1
Structure:
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