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Target
Sepiapterin reductase
Ligand
BDBM660006
Substrate
n/a
Meas. Tech.
Measurement of Human SPR Inhibitory Activity Assay
IC50
0.650±n/a nM
Citation
 KAMAURA, M; INABA, Y; SHINTANI, Y; KUWANO, Y; NAKAO, M; NAGAI, H; KUROSE, N; TAKAYA, K; NAKAJIMA, M CONDENSED HETEROCYCLIC COMPOUND US Patent  US20240092784 Publication Date 3/21/2024
Target
Name:
Sepiapterin reductase
Synonyms:
SPR | SPRE_HUMAN | Sepiapterin reductase (SPR)
Type:
Enzyme
Mol. Mass.:
28050.66
Organism:
Homo sapiens (Human)
Description:
P35270
Residue:
261
Sequence:
MEGGLGRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSGLRVVRVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQVNNYWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDMLFQVLALEEPNVRVLNYAPGPLDTDMQQLARETSVDPDMRKGLQELKAKGKLVDCKVSAQKLLSLLEKDEFKSGAHVDFYDK
  
Inhibitor
Name:
BDBM660006
Synonyms:
(E)-2-Amino-N-cyclopropyl-7-hydroxy-5-oxo-4-((tetrahydro-2H-pyran-4-yl)methyl)-3-(2-(tetrahydro-2H-pyran-4-yl)vinyl)-4,5-dihydropyrazolo[1,5-a]pyrimidine-6-carboxamide hydrochloride | US20240092784, Example 443
Type:
Small organic molecule
Emp. Form.:
C23H31N5O5
Mol. Mass.:
457.5227
SMILES:
Nc1nn2c(O)c(C(=O)NC3CC3)c(=O)n(CC3CCOCC3)c2c1\C=C\C1CCOCC1
Structure:
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