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Target
Sepiapterin reductase
Ligand
BDBM660084
Substrate
n/a
Meas. Tech.
Measurement of Human SPR Inhibitory Activity Assay
IC50
0.590±n/a nM
Citation
 KAMAURA, M; INABA, Y; SHINTANI, Y; KUWANO, Y; NAKAO, M; NAGAI, H; KUROSE, N; TAKAYA, K; NAKAJIMA, M CONDENSED HETEROCYCLIC COMPOUND US Patent  US20240092784 Publication Date 3/21/2024
Target
Name:
Sepiapterin reductase
Synonyms:
SPR | SPRE_HUMAN | Sepiapterin reductase (SPR)
Type:
Enzyme
Mol. Mass.:
28050.66
Organism:
Homo sapiens (Human)
Description:
P35270
Residue:
261
Sequence:
MEGGLGRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSGLRVVRVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQVNNYWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDMLFQVLALEEPNVRVLNYAPGPLDTDMQQLARETSVDPDMRKGLQELKAKGKLVDCKVSAQKLLSLLEKDEFKSGAHVDFYDK
  
Inhibitor
Name:
BDBM660084
Synonyms:
(S,E)-N-Cyclopropyl-7-hydroxy-3-(3-(2-(hydroxymethyl)morpholino)-3-oxoprop-1-en-1-yl)-4-isobutyl-5-oxo-4,5-dihydropyrazolo[1,5-a]pyrimidine-6-carboxamide | US20240092784, Example 521
Type:
Small organic molecule
Emp. Form.:
C22H29N5O6
Mol. Mass.:
459.4956
SMILES:
CC(C)Cn1c2c(\C=C\C(=O)N3CCO[C@H](CO)C3)cnn2c(O)c(C(=O)NC2CC2)c1=O
Structure:
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