Reaction Details Report a problem with these data
Target
Endoplasmic reticulum aminopeptidase 1 (ERAP1)
Ligand
BDBM661110
Substrate
n/a
Meas. Tech.
In Vitro ERAP Activity Assay
IC50
<500±n/a nM
Citation
POULAIN, RD; GEALAGEAS, R; CAMBERLEIN, V; FLEAU, CT; GUILLAUME, V; BOSC, D; DEPREZ, B; SIEROCKI, P ERAP INHIBITORS US Patent US20240101542 Publication Date 3/28/2024
More Info.:
Target
Name:
Endoplasmic reticulum aminopeptidase 1
Synonyms:
APPILS | ARTS1 | Aminopeptidase | ERAP1 | ERAP1_HUMAN | KIAA0525
Type:
PROTEIN
Mol. Mass.:
107232.03
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1473167
Residue:
941
Sequence:
MVFLPLKWSLATMSFLLSSLLALLTVSTPSWCQSTEASPKRSDGTPFPWNKIRLPEYVIPVHYDLLIHANLTTLTFWGTTKVEITASQPTSTIILHSHHLQISRATLRKGAGERLSEEPLQVLEHPRQEQIALLAPEPLLVGLPYTVVIHYAGNLSETFHGFYKSTYRTKEGELRILASTQFEPTAARMAFPCFDEPAFKASFSIKIRREPRHLAISNMPLVKSVTVAEGLIEDHFDVTVKMSTYLVAFIISDFESVSKITKSGVKVSVYAVPDKINQADYALDAAVTLLEFYEDYFSIPYPLPKQDLAAIPDFQSGAMENWGLTTYRESALLFDAEKSSASSKLGITMTVAHELAHQWFGNLVTMEWWNDLWLNEGFAKFMEFVSVSVTHPELKVGDYFFGKCFDAMEVDALNSSHPVSTPVENPAQIREMFDDVSYDKGACILNMLREYLSADAFKSGIVQYLQKHSYKNTKNEDLWDSMASICPTDGVKGMDGFCSRSQHSSSSSHWHQEGVDVKTMMNTWTLQKGFPLITITVRGRNVHMKQEHYMKGSDGAPDTGYLWHVPLTFITSKSDMVHRFLLKTKTDVLILPEEVEWIKFNVGMNGYYIVHYEDDGWDSLTGLLKGTHTAVSSNDRASLINNAFQLVSIGKLSIEKALDLSLYLKHETEIMPVFQGLNELIPMYKLMEKRDMNEVETQFKAFLIRLLRDLIDKQTWTDEGSVSERMLRSQLLLLACVHNYQPCVQRAEGYFRKWKESNGNLSLPVDVTLAVFAVGAQSTEGWDFLYSKYQFSLSSTEKSQIEFALCRTQNKEKLQWLLDESFKGDKIKTQEFPQILTLIGRNPVGYPLAWQFLRKNWNKLVQKFELGSSSIAHMVMGTTNQFSTRTRLEEVKGFFSSLKENGSQLRCVQQTIETIEENIGWMDKNFDKIRVWLQSEKLERM
Inhibitor
Name:
BDBM661110
Synonyms:
(2)-3-(4-methoxyphenyl)-2-[4-[[(2-phenylthiazol-5-yl)sulfonylamino]methyl]triazol-1-yl]propanehydroxamic acid | US20240101542, Compound 56
Type:
Small organic molecule
Emp. Form.:
C22H22N6O5S2
Mol. Mass.:
514.577
SMILES:
COc1ccc(C[C@@H](C(=O)NO)n2cc(CNS(=O)(=O)c3cnc(s3)-c3ccccc3)nn2)cc1 |r|