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Target
Protein cereblon
Ligand
BDBM662951
Substrate
n/a
Meas. Tech.
Cereblon Binding Assay
IC50
648±n/a nM
Citation
 Bian, Z; Burke, JP; Jia, ZJ; Jiang, X; Katcher, MH; Mali, VR; Marin, VL; Noey, EL; Okano, A; Rivkin, AA; Scholz, SO; Woller, KR; Zhao, X; Adams, AM; Biannic, B; Mortezaei, S; Payette, JN; Zablocki, JA PYRIMIDINES FOR DEGRADING BRUTON'S TYROSINE KINASE US Patent  US20240109877 Publication Date 4/4/2024
Target
Name:
Protein cereblon
Synonyms:
CRBN | CRBN_HUMAN
Type:
PROTEIN
Mol. Mass.:
50537.73
Organism:
Homo sapiens (Human)
Description:
ChEMBL_116917
Residue:
442
Sequence:
MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL
  
Inhibitor
Name:
BDBM662951
Synonyms:
US20240109877, Example 5
Type:
Small organic molecule
Emp. Form.:
C42H48FN11O4
Mol. Mass.:
789.9002
SMILES:
C[C@@H](NC(=O)c1nc(no1)C(C)(C)C)c1ccc(cc1C)-c1cc(Nc2ccc(cn2)N2CCN(CCc3ccc(N4CCC(=O)NC4=O)c(F)c3)C[C@H]2C)ncn1 |r|
Structure:
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