Reaction Details  Report a problem with these data
Target
Protein cereblon
Ligand
BDBM662964
Substrate
n/a
Meas. Tech.
Cereblon Binding Assay
IC50
1250±n/a nM
Citation
 Bian, Z; Burke, JP; Jia, ZJ; Jiang, X; Katcher, MH; Mali, VR; Marin, VL; Noey, EL; Okano, A; Rivkin, AA; Scholz, SO; Woller, KR; Zhao, X; Adams, AM; Biannic, B; Mortezaei, S; Payette, JN; Zablocki, JA PYRIMIDINES FOR DEGRADING BRUTON'S TYROSINE KINASE US Patent  US20240109877 Publication Date 4/4/2024
Target
Name:
Protein cereblon
Synonyms:
CRBN | CRBN_HUMAN
Type:
PROTEIN
Mol. Mass.:
50537.73
Organism:
Homo sapiens (Human)
Description:
ChEMBL_116917
Residue:
442
Sequence:
MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL
  
Inhibitor
Name:
BDBM662964
Synonyms:
US20240109877, Example 18
Type:
Small organic molecule
Emp. Form.:
C43H50N10O4
Mol. Mass.:
770.9217
SMILES:
C[C@@H](NC(=O)c1nc(no1)C(C)(C)C)c1ccc(cc1C)-c1cc(Nc2ccc(cc2)N2CCN(CCc3ccc(cc3)N3CCC(=O)NC3=O)C[C@@H]2C)ncn1 |r|
Structure:
Search PDB for entries with ligand similarity: