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Target
Cytochrome P450 1A2
Ligand
US11952364, Example Control
Substrate
n/a
Meas. Tech.
Inhibitory Activity Assay
IC50
6300±n/a nM
Citation
 Zhong, B; Zhang, TY; Cao, Y; Chen, G TRK inhibitors useful as anticancer drugs US Patent  US11952364 Publication Date 4/9/2024
Target
Name:
Cytochrome P450 1A2
Synonyms:
CP1A2_HUMAN | CYP1A2 | CYPIA2 | Cholesterol 25-hydroxylase | Cytochrome P(3)450 | Cytochrome P450 1A | Cytochrome P450 1A2 (CYP1A2) | Cytochrome P450 4 | Cytochrome P450-P3
Type:
Enzyme
Mol. Mass.:
58423.38
Organism:
Homo sapiens (Human)
Description:
P05177
Residue:
516
Sequence:
MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN
  
Inhibitor
Name:
BDBM50028111
Synonyms:
Cis-Platinum(II) | Cisplatin(cis-Diammenedichloroplatinum) | Platinum (II) complex | Platinum(IV) Complex | Pt(II) Complex | camphorato platinum complex derivative | cis-Platinum diamminedichloride | cis-diamminedichloroplatinum(II)(cis-DDP) | cisplatin | cisplatin complex | dichloromethanediamine(platinum complex) | dichloroplatinumdiamine | trans-dichlorodiammineplatinum.(transplatin)
Type:
Small organic molecule
Emp. Form.:
Cl2H4N2Pt
Mol. Mass.:
298.035
SMILES:
N[Pt](N)(Cl)Cl
Structure:
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