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Target
NEDD8-conjugating enzyme UBE2F
Ligand
BDBM320970
Substrate
n/a
Meas. Tech.
Nedd8 Conjugation Inhibitory Activity
IC50
4.80±n/a nM
Citation
 Mizutani, T; Yoshimura, C; Kondo, H; Kitade, M; Ohkubo, S Pyrrolopyrimidine compound or salt thereof and compositions containing the pyrrolopyrimidine compound or salt thereof US Patent  US10174040 Publication Date 1/8/2019
Target
Name:
NEDD8-conjugating enzyme UBE2F
Synonyms:
NCE2 | NEDD8 carrier protein UBE2F | NEDD8 protein ligase UBE2F | NEDD8-conjugating enzyme 2 | RING-type E3 NEDD8 transferase UBE2F | UBE2F | UBE2F_HUMAN | Ubiquitin-conjugating enzyme E2 F
Type:
Enzyme Catalytic Domain
Mol. Mass.:
21077.76
Organism:
Homo sapiens (Human)
Description:
Q969M7
Residue:
185
Sequence:
MLTLASKLKRDDGLKGSRTAATASDSTRRVSVRDKLLVKEVAELEANLPCTCKVHFPDPNKLHCFQLTVTPDEGYYQGGKFQFETEVPDAYNMVPPKVKCLTKIWHPNITETGEICLSLLREHSIDGTGWAPTRTLKDVVWGLNSLFTDLLNFDDPLNIEAAEHHLRDKEDFRNKVDDYIKRYAR
  
Inhibitor
Name:
BDBM320970
Synonyms:
4-Amino-5-[2-[2,6-difluoro-4-(methylamino)phenyl]ethynyl]-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(sulfamoylamino)methyl]tetrahydrofuran-2-yl]pyrrolo[2,3-d]pyrimidine | US10174040, Example 25 | US9963456, Example 25
Type:
Small organic molecule
Emp. Form.:
C20H21F2N7O5S
Mol. Mass.:
509.486
SMILES:
CNc1cc(F)c(C#Cc2cn([C@@H]3O[C@H](CNS(N)(=O)=O)[C@@H](O)[C@H]3O)c3ncnc(N)c23)c(F)c1
Structure:
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