Reaction Details Report a problem with these data
Target
Apolipoprotein L1
Ligand
BDBM615176
Substrate
n/a
Meas. Tech.
Acute APOL1 Thallium Assay
IC50
600±n/a nM
Citation
CAO, J; COME, JH; DAKIN, LA; DENIS, F; DORSCH, WA; FORTIER, A; HAMEL, M; KRUEGER, EB; LEDFORD, B; NANTHAKUMAR, SS; NICOLAS, O; SAYEGH, C; SENTER, TJ; WANG, T; BRODNEY, M; HU, K; ROSE, P; GAGNON, K; SHI, Y; SHRESTHA, M; MEDEK, A; WITKOS, F INHIBITORS OF APOL1 AND METHODS OF USING SAME US Patent US20230271945 Publication Date 8/31/2023
More Info.:
Target
Name:
Apolipoprotein L1
Synonyms:
APOL | APOL1 | APOL1_HUMAN | Apo-L | ApoL-I | Apolipoprotein L | Apolipoprotein L-I | Apolipoprotein L1
Type:
PROTEIN
Mol. Mass.:
43969.63
Organism:
Homo sapiens
Description:
ChEMBL_120089
Residue:
398
Sequence:
MEGAALLRVSVLCIWMSALFLGVGVRAEEAGARVQQNVPSGTDTGDPQSKPLGDWAAGTMDPESSIFIEDAIKYFKEKVSTQNLLLLLTDNEAWNGFVAAAELPRNEADELRKALDNLARQMIMKDKNWHDKGQQYRNWFLKEFPRLKSELEDNIRRLRALADGVQKVHKGTTIANVVSGSLSISSGILTLVGMGLAPFTEGGSLVLLEPGMELGITAALTGITSSTMDYGKKWWTQAQAHDLVIKSLDKLKEVREFLGENISNFLSLAGNTYQLTRGIGKDIRALRRARANLQSVPHASASRPRVTEPISAESGEQVERVNEPSILEMSRGVKLTDVAPVSFFLVLDVVYLVYESKHLHEGAKSETAEELKKVAQELEEKLNILNNNYKILQADQEL
Inhibitor
Name:
BDBM615176
Synonyms:
3-[5,7-difluoro-2-(4-fluorophenyl)-1H-indol-3-yl]-2,2-difluoro-N-[(3S,4R)-4-hydroxy-2-oxo-pyrrolidin-3-yl]propanamide (95) | US20230271945, Compound 95
Type:
Small organic molecule
Emp. Form.:
C21H16F5N3O3
Mol. Mass.:
453.3621
SMILES:
O[C@@H]1CNC(=O)[C@H]1NC(=O)C(F)(F)Cc1c([nH]c2c(F)cc(F)cc12)-c1ccc(F)cc1 |r|