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Target
Apolipoprotein L1
Ligand
BDBM615208
Substrate
n/a
Meas. Tech.
Acute APOL1 Thallium Assay
IC50
600±n/a nM
Citation
 CAO, J; COME, JH; DAKIN, LA; DENIS, F; DORSCH, WA; FORTIER, A; HAMEL, M; KRUEGER, EB; LEDFORD, B; NANTHAKUMAR, SS; NICOLAS, O; SAYEGH, C; SENTER, TJ; WANG, T; BRODNEY, M; HU, K; ROSE, P; GAGNON, K; SHI, Y; SHRESTHA, M; MEDEK, A; WITKOS, F INHIBITORS OF APOL1 AND METHODS OF USING SAME US Patent  US20230271945 Publication Date 8/31/2023
Target
Name:
Apolipoprotein L1
Synonyms:
APOL | APOL1 | APOL1_HUMAN | Apo-L | ApoL-I | Apolipoprotein L | Apolipoprotein L-I | Apolipoprotein L1
Type:
PROTEIN
Mol. Mass.:
43969.63
Organism:
Homo sapiens
Description:
ChEMBL_120089
Residue:
398
Sequence:
MEGAALLRVSVLCIWMSALFLGVGVRAEEAGARVQQNVPSGTDTGDPQSKPLGDWAAGTMDPESSIFIEDAIKYFKEKVSTQNLLLLLTDNEAWNGFVAAAELPRNEADELRKALDNLARQMIMKDKNWHDKGQQYRNWFLKEFPRLKSELEDNIRRLRALADGVQKVHKGTTIANVVSGSLSISSGILTLVGMGLAPFTEGGSLVLLEPGMELGITAALTGITSSTMDYGKKWWTQAQAHDLVIKSLDKLKEVREFLGENISNFLSLAGNTYQLTRGIGKDIRALRRARANLQSVPHASASRPRVTEPISAESGEQVERVNEPSILEMSRGVKLTDVAPVSFFLVLDVVYLVYESKHLHEGAKSETAEELKKVAQELEEKLNILNNNYKILQADQEL
  
Inhibitor
Name:
BDBM615208
Synonyms:
3-[2-(4-chlorophenyl)-1H-indol-3-yl]-N-[(3S,4R)-4-hydroxy-2-oxo-pyrrolidin-3-yl]propanamide (128) | US20230271945, Compound 128
Type:
Small organic molecule
Emp. Form.:
C21H20ClN3O3
Mol. Mass.:
397.855
SMILES:
O[C@@H]1CNC(=O)[C@H]1NC(=O)CCc1c([nH]c2ccccc12)-c1ccc(Cl)cc1 |r|
Structure:
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