Reaction Details  Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM349522
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
18.0±n/a nM
Citation
 Rishton, G; Catalano, SM; Look, GC Isoindoline compositions and methods for treating neurodegenerative disease US Patent  US9796672 Publication Date 10/24/2017
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM349522
Synonyms:
US10207991, Ex. Cpd. No. 38 | US10611728, Example Compound 38 | US11691947, Example 38
Type:
Small organic molecule
Emp. Form.:
C24H32FNO2
Mol. Mass.:
385.5148
SMILES:
CC(C)Oc1ccc(CC[C@@H](C)N2Cc3ccc(F)cc3C2)cc1OC(C)C |r|
Structure:
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