Reaction Details  Report a problem with these data
Target
Tryptophan 5-hydroxylase 2
Ligand
BDBM357742
Substrate
n/a
Meas. Tech.
In Vitro Enzyme Activity Assay
IC50
730±n/a nM
Citation
 Bader, M; Specker, E; Matthes, S; Schütz, A; Mallow, K; Grohmann, M; Nazaré, M Xanthine derivatives, their use as a medicament, and pharmaceutical preparations comprising the same US Patent  US10214530 Publication Date 2/26/2019
Target
Name:
Tryptophan 5-hydroxylase 2
Synonyms:
NTPH | TPH2 | TPH2_HUMAN
Type:
PROTEIN
Mol. Mass.:
56055.12
Organism:
Homo sapiens (Human)
Description:
ChEMBL_487490
Residue:
490
Sequence:
MQPAMMMFSSKYWARRGFSLDSAVPEEHQLLGSSTLNKPNSGKNDDKGNKGSSKREAATESGKTAVVFSLKNEVGGLVKALRLFQEKRVNMVHIESRKSRRRSSEVEIFVDCECGKTEFNELIQLLKFQTTIVTLNPPENIWTEEEELEDVPWFPRKISELDKCSHRVLMYGSELDADHPGFKDNVYRQRRKYFVDVAMGYKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYLKNFPLLTKYCGYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQYIRHGSDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFFTIEFGLCKQEGQLRAYGAGLLSSIGELKHALSDKACVKAFDPKTTCLQECLITTFQEAYFVSESFEEAKEKMRDFAKSITRPFSVYFNPYTQSIEILKDTRSIENVVQDLRSDLNTVCDALNKMNQYLGI
  
Inhibitor
Name:
BDBM357742
Synonyms:
US10214530, LX1031 | US11028104, Example LX1031
Type:
Small organic molecule
Emp. Form.:
C28H25F3N4O4
Mol. Mass.:
538.5177
SMILES:
COc1cccc(c1)-c1ccc(cc1)[C@@H](Oc1cc(nc(N)n1)-c1ccc(CC(N)C(O)=O)cc1)C(F)(F)F |r|
Structure:
Search PDB for entries with ligand similarity: