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Target
Gamma-aminobutyric acid type B receptor subunit 2
Ligand
BDBM360718
Substrate
n/a
Meas. Tech.
GTPgS Binding Assay
EC50
420±n/a nM
Citation
 Faghih, R; Moeller, A; Ochse, M; Pohlki, F; Schmidt, M; Sippy, K; Turner, S; Van Der Kam, EL Substituted pyrazolopyrimidines and method of use US Patent  US9828381 Publication Date 11/28/2017
Target
Name:
Gamma-aminobutyric acid type B receptor subunit 2
Synonyms:
GABA B receptor | GABR2_RAT | Gabbr2 | Gpr51
Type:
PROTEIN
Mol. Mass.:
105775.46
Organism:
Rattus norvegicus
Description:
O88871
Residue:
940
Sequence:
MASPPSSGQPRPPPPPPPPARLLLPLLLSLLLWLAPGAWGWTRGAPRPPPSSPPLSIMGLMPLTKEVAKGSIGRGVLPAVELAIEQIRNESLLRPYFLDLRLYDTECDNAKGLKAFYDAIKYGPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAVNPAILKLLKHFRWRRVGTLTQDVQRFSEVRNDLTGVLYGEDIEISDTESFSNDPCTSVKKLKGNDVRIILGQFDQNMAAKVFCCAFEESMFGSKYQWIIPGWYEPAWWEQVHVEANSSRCLRRSLLAAMEGYIGVDFEPLSSKQIKTISGKTPQQFEREYNSKRSGVGPSKFHGYAYDGIWVIAKTLQRAMETLHASSRHQRIQDFNYTDHTLGKIILNAMNETNFFGVTGQVVFRNGERMGTIKFTQFQDSREVKVGEYNAVADTLEIINDTIRFQGSEPPKDKTIILEQLRKISLPLYSILSALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSEKTFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMKKKIIKDQKLLVIVGGMLLIDLCILICWQAVDPLRRTVERYSMEPDPAGRDISIRPLLEHCENTHMTIWLGIVYAYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQFCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQFTQNQKKEDSKTSTSVTSVNQASTSRLEGLQSENHRLRMKITELDKDLEEVTMQLQDTPEKTTYIKQNHYQELNDILSLGNFTESTDGGKAILKNHLDQNPQLQWNTTEPSRTCKDPIEDINSPEHIQRRLSLQLPILHHAYLPSIGGVDASCVSPCVSPTASPRHRHVPPSFRVMVSGL
  
Inhibitor
Name:
BDBM360718
Synonyms:
US9828381, 8-3
Type:
Small organic molecule
Emp. Form.:
C22H23F3N4O
Mol. Mass.:
416.4394
SMILES:
CC(c1cc2nc(C)cc(N3CCC4(COC4)C3)n2n1)c1ccc(cc1)C(F)(F)F
Structure:
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