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Target
ATP-sensitive inward rectifier potassium channel 1
Ligand
BDBM363487
Substrate
n/a
Meas. Tech.
Electrophysiology Assay
IC50
13.4±n/a nM
Citation
 Pasternak, A; Ding, F; Dong, S; Jiang, J; Tang, H; Gu, X; DeJesus, RK; Frie, J; Fu, Q; Suzuki, T; Pu, Z Inhibitors of the renal outer medullary potassium channel US Patent  US9850245 Publication Date 12/26/2017
Target
Name:
ATP-sensitive inward rectifier potassium channel 1
Synonyms:
ATP-regulated potassium channel ROM-K | ATP-regulated potassium channel ROMK | ATP-sensitive inward rectifier potassium channel 1 | Egl nine homolog 1 | KCNJ1 | KCNJ1_HUMAN | Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | ROMK1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44809.08
Organism:
Homo sapiens (Human)
Description:
gi_223460826
Residue:
391
Sequence:
MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQSRFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTPCVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGETIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLYNEKDVRARMKRGYDNPNFILSEVNETDDTKM
  
Inhibitor
Name:
BDBM363487
Synonyms:
(1R,2'R,5S)-8-((R)-2-hydroxy-2- (4-methyl-1-oxo-1,3- dihydroisobenzofuran-5- yl)ethyl)-4'-(5-oxo-2,5- dihydrofuran-3-yl)-8- azaspiro[bicyclo[3.2.1]octane- 3,2'-morpholin]-3'-one | US9850245, Example 36
Type:
Small organic molecule
Emp. Form.:
C25H28N2O7
Mol. Mass.:
468.499
SMILES:
Cc1c2COC(=O)c2ccc1[C@@H](O)CN1C2CCC1CC1(C2)OCCN(C2=CC(=O)OC2)C1=O |r,t:30,TLB:32:20:14:16.17,13:14:19.20.21:16.17,THB:22:20:14:16.17|
Structure:
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