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Target
Diacylglycerol kinase alpha
Ligand
BDBM615772
Substrate
n/a
Meas. Tech.
DGKalpha and DGKzeta Biochemical Assays
IC50
55±n/a nM
Citation
 Casarez, A; Kellar, T COMPOUNDS USEFUL AS T CELL ACTIVATORS US Patent  US20230271954 Publication Date 8/31/2023
Target
Name:
Diacylglycerol kinase alpha
Synonyms:
2.7.1.107 | 80 kDa diacylglycerol kinase | DAG kinase alpha | DAGK | DAGK1 | DGK-alpha | DGKA | DGKA_HUMAN | Diacylglycerol kinase alpha | Diglyceride kinase alpha
Type:
PROTEIN
Mol. Mass.:
82631.86
Organism:
Homo sapiens
Description:
ChEMBL_117392
Residue:
735
Sequence:
MAKERGLISPSDFAQLQKYMEYSTKKVSDVLKLFEDGEMAKYVQGDAIGYEGFQQFLKIYLEVDNVPRHLSLALFQSFETGHCLNETNVTKDVVCLNDVSCYFSLLEGGRPEDKLEFTFKLYDTDRNGILDSSEVDKIILQMMRVAEYLDWDVSELRPILQEMMKEIDYDGSGSVSQAEWVRAGATTVPLLVLLGLEMTLKDDGQHMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKYTVHDQCAMKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQAVGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNLSTSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQNLAKILKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLEGAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPMLMGPPPRSTNFFGFLS
  
Inhibitor
Name:
BDBM615772
Synonyms:
US20230271954, Compound 71 | trans-8-((4-((cyclopropylmethyl)(o-tolyl)amino) cyclohexyl)(methyl)amino)-5-methyl-6-oxo-5,6- dihydro-1,5-naphthyridine-2,7-dicarbonitrile
Type:
Small organic molecule
Emp. Form.:
C29H32N6O
Mol. Mass.:
480.604
SMILES:
CN([C@H]1CCC(CC1)N(CC1CC1)c1ccccc1C)c1c(C#N)c(=O)n(C)c2ccc(nc12)C#N |r,wU:2.1,(-2.1,-2.7,;-2.1,-1.16,;-.77,-.39,;-.77,1.15,;.56,1.92,;1.9,1.15,;1.9,-.39,;.56,-1.16,;3.23,1.92,;4.56,1.15,;5.9,1.92,;6.67,3.26,;7.44,1.92,;3.23,3.46,;4.56,4.23,;4.56,5.77,;3.23,6.54,;1.9,5.77,;1.9,4.23,;.56,3.46,;-3.44,-.39,;-3.39,1.22,;-2.06,2.01,;-.74,2.79,;-4.77,1.92,;-4.77,3.46,;-6.1,1.15,;-7.44,1.92,;-6.1,-.39,;-7.44,-1.16,;-7.44,-2.7,;-6.1,-3.47,;-4.77,-2.7,;-4.77,-1.16,;-6.1,-5.01,;-6.1,-6.55,)|
Structure:
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