Reaction Details
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Target
Histone deacetylase 4 [653-1084,H976Y]
Ligand
BDBM25163
Substrate
BDBM25143
Meas. Tech.
HDAC Activity Assay
Temperature
298.15±n/a K
IC50
87±n/a nM
Comments
extracted
Citation
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More Info.:
Target
Name:
Histone deacetylase 4 [653-1084,H976Y]
Synonyms:
HDAC4 | HDAC4_HUMAN | Histone Deacetylase 4 (HDAC4) Mutant (H976Y) | Histone deacetylase 4 gain of function (GOF) mutant | KIAA0288
Type:
Catalytic domain
Mol. Mass.:
46476.72
Organism:
Homo sapiens (Human)
Description:
His-tagged HDAC4 GOF(gain of function, H976Y) catalytic domains (T653-L1084) was expressed in E.coli and purified by Nickel-Chelation affinity chromatography and anion exchange (MonoQ) chromatography.
Residue:
432
Sequence:
TTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGYDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVKPAEKRPDEEPMEEEPPL
Inhibitor
Name:
BDBM25163
Synonyms:
CHEMBL497332 | N-methyl-N-(quinoxalin-6-ylmethyl)-5-(2,2,2-trifluoroacetyl)thiophene-2-carboxamide | thiophene derivative, 3i
Type:
Small organic molecule
Emp. Form.:
C17H12F3N3O2S
Mol. Mass.:
379.356
SMILES:
CN(Cc1ccc2nccnc2c1)C(=O)c1ccc(s1)C(=O)C(F)(F)F