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Target
Beta-2 adrenergic receptor
Ligand
BDBM25395
Substrate
BDBM25393
Meas. Tech.
beta2 Adrenergic Receptor Binding Assay
pH
7.4±n/a
Temperature
295.15±n/a K
Ki
>10000±n/a nM
Citation
 Karellas, P; McNaughton, M; Baker, SP; Scammells, PJ Synthesis of bivalent beta2-adrenergic and adenosine A1 receptor ligands. J Med Chem 51:6128-37 (2008) [PubMed]  Article
Target
Name:
Beta-2 adrenergic receptor
Synonyms:
ADRB2 | ADRB2R | ADRB2_HUMAN | B2AR | Beta-2 adrenoceptor | Beta-2 adrenoreceptor
Type:
n/a
Mol. Mass.:
46461.69
Organism:
Homo sapiens (Human)
Description:
P07550
Residue:
413
Sequence:
MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
  
Inhibitor
Name:
BDBM25395
Synonyms:
(2R,3R,4S,5R)-2-{6-[(2-{[2-(3-amino-4-hydroxyphenyl)-2-hydroxyethyl]amino}ethyl)amino]-9H-purin-9-yl}-5-(hydroxymethyl)oxolane-3,4-diol | Bivalent derivative, 12b
Type:
Small organic molecule
Emp. Form.:
C20H27N7O6
Mol. Mass.:
461.4717
SMILES:
Nc1cc(ccc1O)C(O)CNCCNc1ncnc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM25393
Synonyms:
3-iodopindolol | [(2S)-2-hydroxy-3-[(3-iodo-1H-indol-4-yl)oxy]propyl](propan-2-yl)amine | [125I]-(-)iodopindolol
Type:
radiolabeled ligand
Emp. Form.:
C14H19IN2O2
Mol. Mass.:
374.2173
SMILES:
CC(C)NC[C@H](O)COc1cccc2[nH]cc(I)c12
Structure:
Search PDB for entries with ligand similarity: