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Target
Proto-oncogene Wnt-1
Ligand
BDBM383992
Substrate
n/a
Meas. Tech.
The screening assay for Wnt activity
IC50
7.40±n/a nM
Citation
 KC, SK; Wallace, DM; Cao, J; Chiruta, C; Hood, J 2-(1H-indazol-3-yl)-3H-imidazo[4,5-B]pyridine and therapeutic uses thereof US Patent  US10280166 Publication Date 5/7/2019
Target
Name:
Proto-oncogene Wnt-1
Synonyms:
INT1 | Proto-oncogene Int-1 homolog | WNT1 | WNT1_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41006.01
Organism:
Homo sapiens (human)
Description:
P04628
Residue:
370
Sequence:
MGLWALLPGWVSATLLLALAALPAALAANSSGRWWGIVNVASSTNLLTDSKSLQLVLEPSLQLLSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGPHLFGKIVNRGCRETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRRRGPGGPDWHWGGCSDNIDFGRLFGREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKCHGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVLYGNRGSNRASRAELLRLEPEDPAHKPPSPHDLVYFEKSPNFCTYSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHECL
  
Inhibitor
Name:
BDBM383992
Synonyms:
US10280166, Compound 190
Type:
Small organic molecule
Emp. Form.:
C27H25N9O
Mol. Mass.:
491.5471
SMILES:
Cc1cn(cn1)-c1ccnc2[nH]c(nc12)-c1n[nH]c2ccc(cc12)-c1cncc(NC(=O)C(C)(C)C)c1
Structure:
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