Target

Ligand

Substrate

Meas. Tech.

Aurora Kinase Assay

Citation

 Oslob, JD; Romanowski, MJ; Allen, DA; Baskaran, S; Bui, M; Elling, RA; Flanagan, WM; Fung, AD; Hanan, EJ; Harris, S; Heumann, SA; Hoch, U; Jacobs, JW; Lam, J; Lawrence, CE; McDowell, RS; Nannini, MA; Shen, W; Silverman, JA; Sopko, MM; Tangonan, BT; Teague, J; Yoburn, JC; Yu, CH; Zhong, M; Zimmerman, KM; O'Brien, T; Lew, W Discovery of a potent and selective aurora kinase inhibitor. Bioorg Med Chem Lett 18:4880-4 (2008) [PubMed]  Article

More Info.:

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Name:

Aurora kinase B

Synonyms:

AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B

Type:

Protein

Mol. Mass.:

39327.72

Organism:

Homo sapiens (Human)

Description:

Q96GD4

Residue:

344

Sequence:

MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA

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Blast E-value cutoff:

Name:

BDBM26320

Synonyms:

1-phenyl-3-[5-(2-{thieno[3,2-d]pyrimidin-4-ylamino}ethyl)-1,3-thiazol-2-yl]urea | CHEMBL472202 | thieno[3,2-d]pyrimidine analogue, 15

Type:

Small organic molecule

Emp. Form.:

C18H16N6OS2

Mol. Mass.:

396.489

SMILES:

O=C(Nc1ncc(CCNc2ncnc3ccsc23)s1)Nc1ccccc1

Structure:

Search PDB for entries with ligand similarity:

Similarity to this molecule at least:

Name:

FAM-PKAtide

Synonyms:

n/a

Type:

fluorescien-labeled peptide

Mol. Mass.:

1620.33

Organism:

n/a

Description:

n/a

Residue:

14

Sequence:

FAMGRTGRRNSINH