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Target
Interleukin-2
Ligand
BDBM387268
Substrate
n/a
Meas. Tech.
Inhibition of IL-2 secretion
IC50
<100.0±n/a nM
Citation
 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK Oxazoline and isoxazoline derivatives as CRAC modulators US Patent  US10292981 Publication Date 5/21/2019
Target
Name:
Interleukin-2
Synonyms:
IL-2 | IL2 | IL2_HUMAN | INN=Aldesleukin | Interleukin-2 | Interleukin-2 (IL-2) | T-cell growth factor | TCGF
Type:
Enzyme
Mol. Mass.:
17630.05
Organism:
Homo sapiens (Human)
Description:
P60568
Residue:
153
Sequence:
MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT
  
Inhibitor
Name:
BDBM387268
Synonyms:
N-(2′- Chloro-5′-(4-methyl- 5-oxo-4,5-dihydro- 1,3,4-oxadiazol-2-yl)- [1,1′-biphenyl]-4-yl)- 2,6- difluorobenzamide | US10292981, Example 46
Type:
Small organic molecule
Emp. Form.:
C22H14ClF2N3O3
Mol. Mass.:
441.815
SMILES:
Cn1nc(oc1=O)-c1ccc(Cl)c(c1)-c1ccc(NC(=O)c2c(F)cccc2F)cc1
Structure:
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