Reaction Details  Report a problem with these data
Target
Protein tyrosine phosphatase type IVA 3
Ligand
BDBM396097
Substrate
n/a
Meas. Tech.
In Vitro Biochemical Evaluation
IC50
18.0±14 nM
Citation
 Lazo, JS; Sharlow, ER; McQueeney, KE; Wipf, P; Salamoun, JM Inhibitors of PTP4A3 for the treatment of cancer US Patent  US10308663 Publication Date 6/4/2019
Target
Name:
Protein tyrosine phosphatase type IVA 3
Synonyms:
PRL3 | PTP4A3 | Protein-tyrosine phosphatase 4A3 | TP4A3_HUMAN
Type:
PROTEIN
Mol. Mass.:
19546.22
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1461022
Residue:
173
Sequence:
MARMNRPAPVEVSYKHMRFLITHNPTNATLSTFIEDLKKYGATTVVRVCEVTYDKTPLEKDGITVVDWPFDDGAPPPGKVVEDWLSLVKAKFCEAPGSCVAVHCVAGLGRAPVLVALALIESGMKYEDAIQFIRQKRRGAINSKQLTYLEKYRPKQRLRFKDPHTHKTRCCVM
  
Inhibitor
Name:
BDBM396097
Synonyms:
US10308663, JMS-631-053
Type:
Small organic molecule
Emp. Form.:
C13H8N2O2S
Mol. Mass.:
256.28
SMILES:
N=C1c2sc(cc2C(=O)NC1=O)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: