Target
Serine/threonine-protein kinase Chk2 [209-531,Q209M]
Ligand
BDBM34064
Substrate
Histone H1
Meas. Tech.
In Vitro Protein Kinase Assay
pH
7.5±n/a
Temperature
303.15±n/a K
IC50
100±n/a nM
Citation
 Jobson, AGCardellina, JHScudiero, DKondapaka, SZhang, HKim, HShoemaker, RPommier, Y Identification of a Bis-guanylhydrazone [4,4'-Diacetyldiphenylurea-bis(guanylhydrazone); NSC 109555] as a novel chemotype for inhibition of Chk2 kinase. Mol Pharmacol 72:876-84 (2007) [PubMed]  Article
Target
Name:
Serine/threonine-protein kinase Chk2 [209-531,Q209M]
Synonyms:
CDS1 | CHEK2 | CHK2 | CHK2_HUMAN | Checkpoint Kinase (Chk2) | Checkpoint Kinase 2 | RAD53
Type:
Serine/threonine-protein kinase
Mol. Mass.:
36511.81
Organism:
Homo sapiens (Human)
Description:
O96017[209-531,Q209M]
Residue:
323
Sequence:
MSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLSEENESTALPQVLAQPSTSRKRPREGEAEGAE
  
Inhibitor
Name:
BDBM34064
Synonyms:
2-arylbenzimidazole | CHEMBL179583
Type:
Small organic molecule
Emp. Form.:
C20H14ClN3O2
Mol. Mass.:
363.797
SMILES:
NC(=O)c1ccc2nc([nH]c2c1)-c1ccc(Oc2ccc(Cl)cc2)cc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Histone H1
Synonyms:
n/a
Type:
Other Protein Type
Mol. Mass.:
358.43
Organism:
Bos taurus (bovine)
Description:
n/a
Residue:
3
Sequence:
NA